Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

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Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma.

Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. Pairing analysis in the Octet system identified the monoclonal antibodies that bind to overlapping and independent epitopes on human BChE. The nucleotide and amino acid sequences of 4 monoclonal antibodies are deposited in GenBank. Our goal was to det...

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Human butyrylcholinesterase polymorphism: Molecular modeling.

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ژورنال

عنوان ژورنال: Chemico-Biological Interactions

سال: 2016

ISSN: 0009-2797

DOI: 10.1016/j.cbi.2015.11.011